The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix
ligands, cell-surface ligands, and soluble ligands. They are transmembrane αβ heterodimers …

The “integrin” terminology was applied in a 1987 review article (1) to describe a family of
structurally, immunochemically, and functionally related cell-surface heterodimeric …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

The cadherins are a family of homophilic adhesion molecules that play a vital role in the
formation of cellular junctions and in tissue morphogenesis. Members of the integrin family …

Integrins are cell adhesion receptors that communicate biochemical and mechanical signals
in a bidirectional manner across the plasma membrane and thus influence most cellular …

Integrins are αβ heterodimeric cell-surface receptors that are vital to the survival and function
of nucleated cells. They recognize aspartic-acid-or a glutamic-acid-based sequence motifs …

Angiostatin, the N-terminal four kringles (K1–4) of plasminogen, blocks tumor-mediated
angiogenesis and has great therapeutic potential. However, angiostatin's mechanism of anti …

In the leukocyte adhesion deficiency (LAD)-1 syndrome, there is diminished expression of
β2 (CD18) integrins. This is caused by lesions in the β2-subunit gene and gives rise to …

The high affinity interaction of integrin α5β1 with the central cell binding domain (CCBD) of
fibronectin requires both the Arg-Gly-Asp (RGD) sequence (in the 10th type III repeat) and a …

Integrins are metalloproteins whose receptor function is dependent on the interplay between
Mg2+ and Ca2+. Although the specificity of the putative divalent cation binding sites has …