Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Tofacitinib (TF) is a selective oral jakanib approved by the USFDA for the treatment of
rheumatoid arthritis (RA). To overcome the adverse effects of orally administered TF, topical …

Abstract Background Wei-Tong-Xin (WTX) is a traditional Chinese medicine (TCM) that has
been screened and improved in accordance with the famous ancient Chinese formula" Wan …

Background Ulcerative colitis (UC) is the most prevalent chronic inflammatory immune
bowel disease. The modernization of lifestyle accompanied by the stress to cope with the …

Allergic asthma is an inflammatory and chronic condition, which is the most common asthma
phenotype. It is usually defined by sensitivity to environmental allergens and leads to the …

Arsenic (As) is a poisonous metalloid that is toxic to both humans and animals. Drinking
water contamination has been linked to the development of cancer (skin, lung, urinary …

Ulcerative colitis (UC) is an idiopathic, chronic disorder of the intestines characterized by
excessive inflammation and oxidative stress. Loganic acid (LA) is an iridoid glycoside …

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to joint damage
and even permanent disability, seriously affecting patients' quality of life. At present, the …

Abstract Tripterygium hypoglaucum (Levl.) Hutch (THH) has long been used as a remedy for
rheumatoid arthritis (RA) in China. However, it is unclear whether the anti-RA mechanism of …