Studying how genetic predispositions come together with environmental factors to contribute
to complex behavioral outcomes has great potential for advancing the understanding of the …

Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world …

In the past 20 years we have learned a great deal about GABA A receptor (GABA AR)
subtypes, and which behaviors are regulated or which drug effects are mediated by each …

Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …

Excessive alcohol use is the cause of an ongoing public health crisis, and accounts for~ 5%
of global disease burden. A minority of people with recreational alcohol use develop alcohol …

GABAA receptors form the major class of inhibitory neurotransmitter receptors in the
mammalian brain. This review sets out to summarize the evidence that variations in genes …

Aim. Drug abuse and addiction are major public health concerns, with millions of people
worldwide affected by the negative consequences of drug use. To better understand this …

Alcohol dependence is a complex condition with clear genetic factors. Some of the leading
candidate genes code for subunits of the inhibitory GABA A and glycine receptors. These …

GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in
most brain regions and are critical in modulating inhibitory synaptic function. Genetic …

In recent years there has been an increase in the understanding of ethanol actions on the
type A γ-aminobutyric acid chloride channel (GABAAR), a member of the pentameric ligand …