As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Tumor metastasis is the leading cause of mortality among advanced cancer patients.
Understanding its mechanisms and treatment strategies is vital for clinical application …

Although oxaliplatin-based chemotherapy has been effective in the treatment of
hepatocellular carcinoma (HCC), primary or acquired resistance to oxaliplatin remains a …

Radioresistance is the major reason for the failure of radiotherapy in esophageal squamous
cell carcinoma (ESCC). Previous evidence indicated that stanniocalcin 2 (STC2) participates …

The highly expressed oncogenic factor Krüppel‐like factor 5 (KLF5) promotes various
cancerous processes, such as cell growth, survival, anti‐apoptosis, migration and …

Abstract Background Protein arginine methyltransferases (PRMTs) regulate protein
biological activity by modulating arginine methylation in cancer and are increasingly …

Purpose Triple-negative breast cancer (TNBC) is the most aggressive breast cancer
subgroup characterized by a high risk of resistance to chemotherapies and high relapse …

α‐Synuclein (αS) is a key molecule in the pathomechanism of Parkinson's disease. Most
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …

Cancer progression depends on the communication between tumor cells and tumor
microenvironment. Cancer-associated fibroblasts (CAFs) are a major component of stromal …

Simple Summary Medulloblastoma is the most prevalent intracerebellar pediatric brain
tumor, accounting for approximately 20% of all childhood brain tumors and over 60% of …