Breakthroughs and applications of organ-on-a-chip technology

MC Koyilot, P Natarajan, CR Hunt, S Sivarajkumar… - Cells, 2022 - mdpi.com
Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …

Targeting the redox system for cardiovascular regeneration in aging

MS Allemann, P Lee, JH Beer, SS Saeedi Saravi - Aging Cell, 2023 - Wiley Online Library
Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Durable immunomodulatory nanofiber niche for the functional remodeling of cardiovascular tissue

Y Liu, L Wang, Z Liu, Y Kang, T Chen, C Xu, T Zhu - ACS nano, 2023 - ACS Publications
Functional remodeling and prolonged anti-inflammatory responses are both vital for
repairing damage in the cardiovascular system. Although these aspects have each been …

Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis

D Zhang, J Ning, T Ramprasath, C Yu, X Zheng… - Nature …, 2022 - nature.com
Abstract Indoleamine 2, 3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine
metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that …

[HTML][HTML] Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation

X Lu, B Yang, R Qi, Q Xie, T Li, J Yang, T Tong… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Previous studies have suggested that myocardial inflammation plays a critical
role after ischemic myocardial infarction (MI); however, the underlying mechanisms still need …

The orchestration of cell-cycle reentry and ribosome biogenesis network is critical for cardiac repair

Y Wang, J Tu, W Wu, Y Xu, Y Li, X Pan, B Liu… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Myocardial infarction (MI) is a severe global clinical condition with widespread
prevalence. The adult mammalian heart's limited capacity to generate new cardiomyocytes …

[HTML][HTML] MicroRNAs and therapeutic potentials in acute and chronic cardiac disease

R Song, L Zhang - Drug Discovery Today, 2024 - Elsevier
Abstract microRNAs (miRNAs) are small regulatory RNAs implicated in various cardiac
disorders. In this review, the role of miRNAs is discussed in relation to acute myocardial …

Self-assembling peptide RADA16: a promising scaffold for tissue engineering and regenerative medicine

X Yao, Y Hu, M Lin, K Peng, P Wang, Y Gao, X Gao… - …, 2023 - Taylor & Francis
RADA16 is a peptide-based biomaterial whose acidic aqueous solution spontaneously
forms an extracellular matrix-like 3D structure within seconds upon contact with …

The knowns and unknowns of cardiac autoimmunity in viral myocarditis

K Mone, J Reddy - Reviews in Medical Virology, 2023 - Wiley Online Library
Myocarditis can result from various infectious and non‐infectious causes that can lead to
dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are …

[HTML][HTML] 3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction

CD Roche, H Lin, Y Huang, CE de Bock, D Beck… - Bioprinting, 2023 - Elsevier
Epicardial transplantation of 3D bioprinted patches represents a promising protective
strategy against infarction-induced myocardial damage. We previously showed that 3D …