ABSTRACT Cyclin-dependent kinase 9 (CDK9) is critical for RNA Polymerase II (Pol II)
transcription initiation, elongation, and termination in several key biological processes …

Although potent combination antiretroviral therapy can effectively block viral replication in
the host, human immunodeficiency virus (HIV) persists due to the existence of latent but …

Protein phosphatases and kinases control multiple cellular events including proliferation,
differentiation, and stress responses through regulating reversible protein phosphorylation …

Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a
critical step regulating gene expression in multicellular organisms. The transition of Pol II …

Emerging evidence has demonstrated that alternative splicing has a vital role in regulating
protein function, but how alternative splicing factors can be regulated remains unclear. We …

DNA damage response (DDR) involves dramatic transcriptional alterations, the mechanisms
of which remain ill defined. Here, we show that following genotoxic stress, the RNA-binding …

Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot
be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is …

The ubiquitin specific protease, USP7, regulates multiple cellular pathways relevant for
cancer through its ability to bind and sometimes stabilize specific target proteins through …

Background: We recently identified 156 proteins in human plasma that were each
associated with the net Framingham Cardiovascular Disease Risk Score using an aptamer …

Conversion of promoter-proximally paused RNA polymerase II (RNAPII) into elongating
polymerase by the positive transcription elongation factor b (P-TEFb) is a central regulatory …