Motor abnormalities: from neurodevelopmental to neurodegenerative through “functional”(neuro) psychiatric disorders

V Peralta, MJ Cuesta - Schizophrenia bulletin, 2017 - academic.oup.com
Abstract Background Motor abnormalities (MAs) of severe mental disorders have been
traditionally neglected both in clinical practice and research, although they are an increasing …

A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia

SL Matheson, AM Shepherd, KR Laurens… - Schizophrenia research, 2011 - Elsevier
INTRODUCTION: Identifying the relative strength of evidence associated with non-genetic
risk factors and putative antecedents of schizophrenia will guide research and may inform …

Motor dysfunction within the schizophrenia-spectrum: a dimensional step towards an underappreciated domain

D Hirjak, PA Thomann, KM Kubera, ND Wolf… - Schizophrenia …, 2015 - Elsevier
At the beginning of the 20th century, genuine motor abnormalities (GMA) were considered to
be intricately linked to schizophrenia. Subsequently, however, GMA have been increasingly …

A systematic review of the prognostic value of motor abnormalities on clinical outcome in psychosis

LE Pieters, N Nadesalingam, S Walther… - Neuroscience & …, 2022 - Elsevier
Schizophrenia spectrum disorders have heterogeneous outcomes and currently no marker
predicts the course of illness. Motor abnormalities (MAs) are inherent to psychosis, the risk of …

Motor dysfunction as research domain in the period preceding manifest schizophrenia: a systematic review

D Hirjak, A Meyer-Lindenberg, KM Kubera… - Neuroscience & …, 2018 - Elsevier
Schizophrenia is a severe behavioral syndrome of neurodevelopmental nature marked by
primary or genuine motor abnormalities (GMA), which refer to spontaneous and medication …

Research Review: Do motor deficits during development represent an endophenotype for schizophrenia? A meta‐analysis

BK Burton, C Hjorthøj, JR Jepsen… - Journal of Child …, 2016 - Wiley Online Library
Background Early detection of schizophrenia risk is a critical goal in the field.
Endophenotypes in children to relatives of affected individuals may contribute to this early …

Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia

XL Cai, YM Wang, Y Wang, HY Zhou… - Schizophrenia …, 2021 - academic.oup.com
Cerebellar dysfunction is associated with neurological soft signs (NSS), which is a promising
endophenotype for schizophrenia spectrum disorders. However, the relationship between …

Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders

RCK Chan, W Xie, F Geng, Y Wang… - Schizophrenia …, 2016 - academic.oup.com
Neurological soft signs (NSSs) bear the promise for early detection of schizophrenia
spectrum disorders. Nonetheless, the sensitivity and specificity of NSSs in the psychosis …

Neurological signs at the first psychotic episode as correlates of long-term outcome: results from the AESOP-10 study

NP Ferruccio, S Tosato, JM Lappin… - Schizophrenia …, 2021 - academic.oup.com
Minor neurological signs are subtle deficits in sensory integration, motor coordination, and
sequencing of complex motor acts present in excess in the early stages of psychosis. Still, it …

Neurological soft signs in bipolar disorder in comparison to healthy controls and schizophrenia: A meta-analysis

E Bora, Ö Akgül, D Ceylan, A Özerdem - European …, 2018 - Elsevier
Neurological soft signs (NSS) are subtle deficits in motor coordination, sensory integration,
and sequencing of complex motor acts. Increased NSS is a well-established feature of …