Disease overview Chronic lymphocytic leukemia (CLL) is one of the most frequent types of
leukemia. It typically occurs in elderly patients and has a highly variable clinical course …

Abstract Disease Overview Chronic lymphocytic leukemia (CLL) is the commonest leukemia
in western countries. The disease typically occurs in elderly patients and has a highly …

Disease overview Chronic lymphocytic leukemia (CLL) is the commonest leukemia in
western countries. The disease typically occurs in elderly patients and has a highly variable …

Disease overview: Chronic lymphocytic leukemia (CLL) is the commonest leukemia in
western countries. The disease typically occurs in elderly patients and has a highly variable …

The B-cell receptor (BCR) is a key survival molecule for normal B cells and for most B-cell
malignancies. Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of …

MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression that play roles
in human diseases, including cancer. Each miRNA is predicted to regulate hundreds of …

We investigated the role of glycogen synthase kinase-3 (GSK-3), which is inactivated by
AKT, for its role in the regulation of apoptosis. Upon IL-3 withdrawal, protein levels of MCL-1 …

The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis,
differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central …

Background Bruton tyrosine kinase (BTK) inhibitors have demonstrated a high degree of
efficacy in the treatment of B cell malignancies characterized by constitutive B cell receptor …

Purpose: Bruton's tyrosine kinase (BTK) is a critical enzyme in the B-cell receptor pathway
and is inhibited by ibrutinib due to covalent binding to the kinase domain. Though ibrutinib …