Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

The description of “serum sickness” more than a century ago in humans transfused with
animal sera eventually led to identification of a class of human antibodies directed against …

Isolation of metastatic circulating tumor cells (CTCs) from cancer patients is of high value for
disease monitoring and molecular characterization. Despite the development of many new …

Histopathological examination (biopsy) is the “gold standard” for the diagnosis of colorectal
cancer (CRC). However, biopsy is an invasive method, and due to the temporal and spatial …

Molecular similarities between embryonic and malignant cells can be exploited to target
tumors through specific signatures absent in healthy adult tissues. One such embryonic …

Metastasis is the main cause of death in cancer patients. The efficacy of pharmacological
therapy for cancer is limited by the heterogeneous nature of cancer cells and the lack of …

Diffuse gliomas are the most common primary malignant brain tumor. Although extracranial
metastases are rarely observed, recent studies have shown the presence of circulating …

Numerous studies point out serglycin as an important regulator of tumorigenesis in a variety
of malignancies. Serglycin expression correlates with the aggressive phenotype of tumor …

Glycosaminoglycans are often deprioritized as targets for synthetic immunotherapy due to
the complexity of glyco-epitopes and limited options for obtaining specific subtype binding …

Chondroitin sulfate proteoglycans (CSPGs) are important components of brain extracellular
matrix (ECM), although their contribution in gliomagenesis remains underinvestigated. Here …