RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Heat waves, the new normal: summertime temperature extremes will impact animals, ecosystems, and human communities

JH Stillman - Physiology, 2019 - journals.physiology.org
A consequence of climate change is the increased frequency and severity of extreme heat
waves. This is occurring now as most of the warmest summers and most intense heat waves …

Genome and transcriptome mechanisms driving cephalopod evolution

CB Albertin, S Medina-Ruiz, T Mitros… - Nature …, 2022 - nature.com
Cephalopods are known for their large nervous systems, complex behaviors and
morphological innovations. To investigate the genomic underpinnings of these features, we …

A-to-I RNA editing—immune protector and transcriptome diversifier

E Eisenberg, EY Levanon - Nature Reviews Genetics, 2018 - nature.com
Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Direct identification of A-to-I editing sites with nanopore native RNA sequencing

TA Nguyen, JWJ Heng, P Kaewsapsak, EPL Kok… - Nature …, 2022 - nature.com
Inosine is a prevalent RNA modification in animals and is formed when an adenosine is
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …

RNA editing: Expanding the potential of RNA therapeutics

BJ Booth, S Nourreddine, D Katrekar, Y Savva, D Bose… - Molecular Therapy, 2023 - cell.com
RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …

Temperature-dependent RNA editing in octopus extensively recodes the neural proteome

MA Birk, N Liscovitch-Brauer, MJ Dominguez… - Cell, 2023 - cell.com
In poikilotherms, temperature changes challenge the integration of physiological function.
Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods …

[HTML][HTML] Trade-off between transcriptome plasticity and genome evolution in cephalopods

N Liscovitch-Brauer, S Alon, HT Porath, B Elstein… - Cell, 2017 - cell.com
RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond
the genomic blueprint; however it is infrequently used among animals for this purpose …

Experimental evidence for the functional importance and adaptive advantage of A-to-I RNA editing in fungi

K Xin, Y Zhang, L Fan, Z Qi, C Feng… - Proceedings of the …, 2023 - National Acad Sciences
Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in animals,
and it occurs in fungi specifically during sexual reproduction. However, it is debatable …

The integrative physiology of insect chill tolerance

J Overgaard, HA MacMillan - Annual review of physiology, 2017 - annualreviews.org
Cold tolerance is important in defining the distribution of insects. Here, we review the
principal physiological mechanisms underlying homeostatic failure during cold exposure in …