To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

The circadian nature of physiology and behavior is regulated by a circadian clock that
generates intrinsic rhythms with a periodicity of approximately 24 h. The mammalian …

Life is a cyclical chemical process that is regulated in four dimensions. We distinguish parts
of the cycle: development describes the changes from single cell to adult, and aging the …

Regulation of circadian period in humans was thought to differ from that of other species,
with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 …

Circadian oscillations in mammalian physiology and behavior are regulated by an
endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known …

We determined that two mouse cryptochrome genes, mCry1 and mCry2, act in the negative
limb of the clock feedback loop. In cell lines, mPER proteins (alone or in combination) have …

SUMMARY PAS domains are newly recognized signaling domains that are widely
distributed in proteins from members of the Archaea and Bacteria and from fungi, plants …

Response to the gaseous plant hormone ethylene in Arabidopsis requires the EIN3/EIL
family of nuclear proteins. The biochemical function (s) of EIN3/EIL proteins, however, has …

Employing the clear, student-friendly style that made previous editions so popular, Insect
Physiology and Biochemistry, Fourth Edition presents an engaging and authoritative guide …