Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the
efficacy of cardioprotective interventions prior to clinical translation. Nonetheless, current …

Background Bone marrow mesenchymal stromal cells (BMMSC s) are cardioprotective in
acute myocardial infarction (AMI) because of release of paracrine angiogenic and …

Background Gene therapy has been proposed as a strategy to induce cardiac regeneration
following acute myocardial infarction (AMI). Given that Tbx20, a transcription factor of the T …

Ovine models of ischemic heart disease and cardiac failure are increasingly used in
translational research. However, reliable extrapolation of the results to the clinical setting …

Mesenchymal stromal cells (MSCs) are cardioprotective in acute myocardial infarction (AMI).
Besides, we have shown that intramyocardial injection of plasmid-VEGF 165 (pVEGF) in …

We discuss large animal translational models of arrhythmia susceptibility and sudden
cardiac death, focusing on important considerations when interpreting the data derived …

The adult mammalian cardiomyocyte has a very limited capacity to reenter the cell cycle and
advance into mitosis. Therefore, diseases characterized by lost contractile tissue usually …

Ischaemic heart disease remains a leading cause of premature mortality and morbidity.
Understanding the associated pathophysiological mechanisms of cardiac dysfunction …

MicroRNAs (miRNAs or miRs) are small regulatory RNAs crucial for modulation of signaling
pathways in multiple organs. While the link between miRNAs and heart disease has grown …