Evaluation of the Pfs25-IMX313/Matrix-M malaria transmission-blocking candidate vaccine in endemic settings
Malaria control relies heavily on the use of anti-malarial drugs and insecticides against
malaria parasites and mosquito vectors. Drug and insecticide resistance threatens the …
malaria parasites and mosquito vectors. Drug and insecticide resistance threatens the …
ApiAP2 Gene‐Network Regulates Gametocytogenesis in Plasmodium Parasites
Malaria is a mosquito‐borne infectious disease, caused by unicellular Apicomplexan
protozoa of the genus Plasmodium. The sexual stage of Plasmodium is one of the most …
protozoa of the genus Plasmodium. The sexual stage of Plasmodium is one of the most …
Targeting Gametocytes of the Malaria Parasite Plasmodium falciparum in a Functional Genomics Era: Next Steps
Mosquito transmission of the deadly malaria parasite Plasmodium falciparum is mediated by
mature sexual forms (gametocytes). Circulating in the vertebrate host, relatively few …
mature sexual forms (gametocytes). Circulating in the vertebrate host, relatively few …
HIV-1 impact on malaria transmission: a complex and relevant global health concern
A Roberds, E Ferraro, S Luckhart… - Frontiers in Cellular and …, 2021 - frontiersin.org
Malaria/HIV-1 co-infection has become a significant public health problem in the tropics
where there is geographical overlap of the two diseases. It is well described that co-infection …
where there is geographical overlap of the two diseases. It is well described that co-infection …
Functional food for the stimulation of the immune system against malaria
T Bamgbose, AR Anvikar, P Alberdi… - Probiotics and …, 2021 - Springer
Drug resistance has become a threat to global health, and new interventions are needed to
control major infectious diseases. The composition of gut microbiota has been linked to …
control major infectious diseases. The composition of gut microbiota has been linked to …
Progress in the development of subunit vaccines against malaria
M Skwarczynski, S Chandrudu, B Rigau-Planella… - Vaccines, 2020 - mdpi.com
Malaria is a life-threatening disease and one of the main causes of morbidity and mortality in
the human population. The disease also results in a major socio-economic burden. The …
the human population. The disease also results in a major socio-economic burden. The …
Immune selection suppresses the emergence of drug resistance in malaria parasites but facilitates its spread
Although drug resistance in Plasmodium falciparum typically evolves in regions of low
transmission, resistance spreads readily following introduction to regions with a heavier …
transmission, resistance spreads readily following introduction to regions with a heavier …
Malaria transmission blocking activity of Anopheles stephensi alanyl aminopeptidase N antigen formulated with MPL, CpG, and QS21 adjuvants
Backgrounds Malaria, a preventive and treatable disease, is still responsible for annual
deaths reported in most tropical regions, principally in sub-Saharan Africa. Subunit …
deaths reported in most tropical regions, principally in sub-Saharan Africa. Subunit …
Deciphering host immunity to malaria using systems immunology
A century of conceptual and technological advances in infectious disease research has
changed the face of medicine. However, there remains a lack of effective interventions and a …
changed the face of medicine. However, there remains a lack of effective interventions and a …
Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya
KO Ochwedo, SA Onyango, CJ Omondi, PW Orondo… - Plos one, 2022 - journals.plos.org
Background Leading transmission-blocking vaccine candidates such as Plasmodium
falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may …
falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may …