Multiple studies have investigated global DNA methylation profiles and gene-specific DNA
methylation in blood-based DNA to develop powerful screening markers for cancer. This …

Highlights•Microfluidic platforms enable the analysis and detection of cancer biomarkers.•
Circulating tumor cells can be separated on-chip from whole blood using several …

A method of treating a patient who has non-small cell lung carcinoma (NSCLC), lung cancer,
gastric cancer, and/or glioblastoma includes administering to said patient a composition …

Purpose The DNA methylation mediated by specific DNA methyltransferases (DNMTs),
results in the epigenetic silencing of multiple genes which are implicated in human breast …

The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …

The use of biomarkers ensures breast cancer patients receive optimal treatment.
Established biomarkers such as estrogen receptor (ER) and progesterone receptor (PR) …

The present invention relates to peptides, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …

The Slit family of guidance cues binds to Roundabout (Robo) receptors and modulates cell
migration. We report here that ectopic expression of Slit2 and Robo1 or recombinant Slit2 …

We determined if soy isoflavones have dose-related estrogenic and methylation effects.
Thirty-four healthy premenopausal women were randomized to 40 mg or 140 mg …

The genes encoding Slits and their Robo receptors are silenced in many types of cancer,
including breast, suggesting a role for this signaling pathway in suppressing tumorigenesis …