Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need,
especially as diagnosis in this population might lead to the greatest loss of years of life …

Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a
complex genetic and environmental aetiology. Unlike cancers with known environmental …

Background Gene-set enrichment analysis is a useful technique to help functionally
characterize large gene lists, such as the results of gene expression experiments. This …

The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical
behaviour and response to therapy translates into an urgent need for robust molecular …

Motivation: Gene expression class comparison studies may identify hundreds or thousands
of genes as differentially expressed (DE) between sample groups. Gaining biological insight …

Cancer cells are typically subject to profound metabolic alterations, including the Warburg
effect wherein cancer cells oxidize a decreased fraction of the pyruvate generated from …

Metastasis is the major cause of cancer mortality. We aimed to find a metastasis-prone
signature for early stage mismatch-repair proficient sporadic colorectal cancer (CRC) …

An uncharacterized gene locus (Chr16: hCG_1815491), now named colorectal neoplasia
differentially expressed (gene symbol CRNDE), is activated early in colorectal neoplasia …

CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-
coding), a long non-coding RNA (lncRNA) gene that expresses multiple splice variants and …

Sphingolipid metabolites have emerged as critical players in a number of fundamental
biological processes. Among them, sphingosine-1-phosphate (S1P) promotes cell survival …