Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone
stimulates glucose uptake and suppresses glucose production. Defects in both the …

Membrane contact sites (MCSs) serve as a zone for nonvesicular lipid transport by oxysterol-
binding protein (OSBP)-related proteins (ORPs). ORPs mediate lipid countertransport, in …

Lipids must be correctly transported within the cell to the right place at the right time in order
to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer …

Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis
involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations …

Numerous genes whose mutations cause, or increase the risk of, Parkinson's disease (PD)
have been identified. An inactivating mutation (R258Q) in the Sac inositol phosphatase …

Some Parkinson's disease (PD)-causative/risk genes, including the PD-associated kinase
leucine-rich repeat kinase 2 (LRRK2), are involved in membrane dynamics. Although …

Summary Phosphatidylinositol 4-phosphate (PI4P) is a low abundant phospholipid with
important roles in lipid transport and membrane trafficking. However, little is known of its …

Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation
process that involves changes in the protein and lipid composition of the granules. Here, we …

Phosphoinositides (PIs) have critical roles in various cellular, physiological, developmental,
pathological, and infectious processes. They are signaling phospholipids that can affect …