Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …

Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

The synaptic transmission in the mammalian brain is not limited to the interplay between the
pre-and the postsynapse of neurons, but involves also astrocytes as well as extracellular …

Epilepsy and intellectual disability are associated with rare variants in the GluN2A and
GluN2B (encoded by GRIN2A and GRIN2B) subunits of the N-methyl-D-aspartate receptor …

Developing cortical GABAergic interneurons rely on genetic programs, neuronal activity, and
environmental cues to construct inhibitory circuits during early postnatal development …

The N-methyl-d-aspartate receptor hypofunction is one of the most prevalent models of
schizophrenia. For example, healthy subjects treated with uncompetitive N-methyl-d …