Roles of HLA-G in the maternal-fetal immune microenvironment

X Xu, Y Zhou, H Wei - Frontiers in immunology, 2020 - frontiersin.org
During pregnancy, the maternal uterus and fetus form a special microenvironment at the
maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs) …

HLA-G genotype/expression/disease association studies: success, hurdles, and perspectives

G Amodio, S Gregori - Frontiers in Immunology, 2020 - frontiersin.org
The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological
condition, HLA-G surface expression is restricted to the maternal–fetal interface and to …

A review of the main genetic factors influencing the course of COVID-19 in Sardinia: the role of human leukocyte antigen-G

S Mocci, R Littera, L Chessa, M Campagna… - Frontiers in …, 2023 - frontiersin.org
Introduction A large number of risk and protective factors have been identified during the
SARS-CoV-2 pandemic which may influence the outcome of COVID-19. Among these …

Role of HLA-G in viral infections

S Jasinski-Bergner, D Schmiedel… - Frontiers in …, 2022 - frontiersin.org
The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has
distinct features to classical HLA-A,-B,-C antigens, such as a low polymorphism, different …

HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis

V Peris Sempere, G Luo, S Muñiz-Castrillo… - Frontiers in …, 2024 - frontiersin.org
Introduction Genetic predisposition to autoimmune encephalitis with antibodies against N-
methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of …

Advances in the study of HLA class Ib in maternal-fetal immune tolerance

Y Yang, W Wang, J Weng, H Li, Y Ma, L Liu… - Frontiers in …, 2022 - frontiersin.org
The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of
individual human and plays an important role in maternal-fetal immune tolerance. Early …

Role of the HLA-G immune checkpoint molecule in pregnancy

N Rouas-Freiss, P Moreau, J LeMaoult, B Papp… - Human Immunology, 2021 - Elsevier
The non-classical HLA class I molecule HLA-G is expressed in trophoblasts where it
contributes to maternal-fetal tolerance. HLA-G has been implicated in the control of …

The severity of COVID-19 affects the plasma soluble levels of the immune checkpoint HLA-G molecule

JFC Cordeiro, TM Fernandes, DM Toro… - International journal of …, 2022 - mdpi.com
The non-classical histocompatibility antigen G (HLA-G) is an immune checkpoint molecule
that has been implicated in viral disorders. We evaluated the plasma soluble HLA-G (sHLA …

Association of HLA gene polymorphisms with Helicobacter pylori related gastric cancer—a systematic review

MT Mahmud, F Ahmed, MJ Rana, MA Rahman, A Atta… - HLA, 2024 - Wiley Online Library
The appropriate host cell immune responses for the progression of several diseases,
including gastric or stomach cancer (GC), are significantly influenced by HLA …

Biological characteristics of HLA-G and its role in solid organ transplantation

S Liu, NA Bos, EAM Verschuuren… - Frontiers in …, 2022 - frontiersin.org
Organ transplantation is a lifesaving option for patients with advanced diseases. Rejection is
regarded as one of the most severe risk factors post-transplantation. A molecule that …