The case for a renewed focus on Nature in drug discovery is reviewed; not in terms of
natural product screening, but how and why biomimetic molecules, especially those …

The field of fragment-based drug discovery (FBDDa) has developed significantly over the
past 10 years and is now recognized as a tangible alternative to more traditional methods of …

Fragment-based ligand and drug discovery predominantly employs sp 2-rich compounds
covering well-explored regions of chemical space. Despite the ease with which such …

The pandemic prevalence of COVID-19 has become a very serious global health issue.
Scientists all over the world have been seriously attempting in the discovery of a drug to …

Fragment screens have successfully identified new scaffolds in drug discovery, often with
relatively high hit rates (5%) using small screening libraries (1,000–10,000 compounds) …

Fragment based drug design has emerged as an effective alternative to high throughput
screening for the identification of lead compounds in drug discovery in the past fifteen years …

Accurate and efficient prediction of protein-ligand interactions has been a long-lasting
dream of practitioners in drug discovery. The insufficient treatment of hydration is widely …

Fragment-based drug design (FBDD) has become an effective methodology for drug
development for decades. Successful applications of this strategy brought both opportunities …

Fragment-based methods have emerged as a new strategy for drug discovery. The main
advantages are that useful starting points for lead identification for most targets can be …

This chapter summarizes the experience at Vernalis over the past decade in developing and
applying fragment-based discovery methods across a range of different targets. The …