Synthetic Fe/Cu complexes: toward understanding heme-copper oxidase structure and function

SM Adam, GB Wijeratne, PJ Rogler, DE Diaz… - Chemical …, 2018 - ACS Publications
Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …

Molecular enzymology of lipoxygenases

I Ivanov, D Heydeck, K Hofheinz, J Roffeis… - Archives of biochemistry …, 2010 - Elsevier
Lipoxygenases (LOXs) are lipid peroxidizing enzymes, implicated in the pathogenesis of
inflammatory and hyperproliferative diseases, which represent potential targets for …

AlphaFill: enriching AlphaFold models with ligands and cofactors

ML Hekkelman, I de Vries, RP Joosten, A Perrakis - Nature Methods, 2023 - nature.com
Artificial intelligence-based protein structure prediction approaches have had a
transformative effect on biomolecular sciences. The predicted protein models in the …

Rapid Biomolecular Trifluoromethylation Using Cationic Aromatic Sulfonate Esters as Visible-Light-Triggered Radical Photocages

NJ Kuehl, MT Taylor - Journal of the American Chemical Society, 2023 - ACS Publications
Described here is a photodecaging approach to radical trifluoromethylation of biomolecules.
This was accomplished by designing a quinolinium sulfonate ester that, upon absorption of …

Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation

TRM Barends, L Foucar, A Ardevol, K Nass, A Aquila… - Science, 2015 - science.org
The hemoprotein myoglobin is a model system for the study of protein dynamics. We used
time-resolved serial femtosecond crystallography at an x-ray free-electron laser to resolve …

Slaving: solvent fluctuations dominate protein dynamics and functions

PW Fenimore, H Frauenfelder… - Proceedings of the …, 2002 - National Acad Sciences
Protein motions are essential for function. Comparing protein processes with the dielectric
fluctuations of the surrounding solvent shows that they fall into two classes: nonslaved and …

Watching a protein as it functions with 150-ps time-resolved x-ray crystallography

F Schotte, M Lim, TA Jackson, AV Smirnov, J Soman… - Science, 2003 - science.org
We report picosecond time-resolved x-ray diffraction from the myoglobin (Mb) mutant in
which Leu29 is replaced by Phe (L29Fmutant). The frame-by-frame structural evolution …

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

I Ivanov, H Kuhn, D Heydeck - Gene, 2015 - Elsevier
Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes, which have been
implicated in a number of physiological processes and in the pathogenesis of inflammatory …

Influence of pump laser fluence on ultrafast myoglobin structural dynamics

TRM Barends, A Gorel, S Bhattacharyya, G Schirò… - Nature, 2024 - nature.com
High-intensity femtosecond pulses from an X-ray free-electron laser enable pump–probe
experiments for the investigation of electronic and nuclear changes during light-induced …

The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin

H Frauenfelder, BH McMahon… - Proceedings of the …, 2001 - National Acad Sciences
The grail of protein science is the connection between structure and function. For myoglobin
(Mb) this goal is close. Described as only a passive dioxygen storage protein in texts, we …