Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis
Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …
which can be compared across CNS regions, patients, and centres. In patients with multiple …
Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …
with water between the wraps. The measurement of damage to the myelin sheaths, the …
7T MRI differentiates remyelinated from demyelinated multiple sclerosis lesions
Objective To noninvasively assess myelin status in chronic white matter lesions of multiple
sclerosis (MS), we developed and evaluated a simple classification scheme based on T1 …
sclerosis (MS), we developed and evaluated a simple classification scheme based on T1 …
MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial
Myelin repair is an unrealized therapeutic goal in the treatment of multiple sclerosis (MS).
Uncertainty remains about the optimal techniques for assessing therapeutic efficacy and …
Uncertainty remains about the optimal techniques for assessing therapeutic efficacy and …
Remyelination alters the pattern of myelin in the cerebral cortex
J Orthmann-Murphy, CL Call, GC Molina-Castro… - Elife, 2020 - elifesciences.org
Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters
neural activity and is associated with cognitive disability in multiple sclerosis (MS). Myelin …
neural activity and is associated with cognitive disability in multiple sclerosis (MS). Myelin …
Anti-inflammatory and neuroprotective agents in clinical trials for CNS disease and injury: where do we go from here?
K Mallah, C Couch, DM Borucki, A Toutonji… - Frontiers in …, 2020 - frontiersin.org
Neurological disorders are major contributors to death and disability worldwide. The
pathology of injuries and disease processes includes a cascade of events that often involve …
pathology of injuries and disease processes includes a cascade of events that often involve …
Progressive multiple sclerosis
L Amezcua - CONTINUUM: Lifelong Learning in Neurology, 2022 - journals.lww.com
PURPOSE OF REVIEW This article provides an update on progressive forms of multiple
sclerosis (MS) commonly referred to as primary progressive MS and secondary progressive …
sclerosis (MS) commonly referred to as primary progressive MS and secondary progressive …
Diagnosis and management of progressive multiple sclerosis
G Macaron, D Ontaneda - Biomedicines, 2019 - mdpi.com
Multiple sclerosis is a chronic autoimmune disease of the central nervous system that results
in varying degrees of disability. Progressive multiple sclerosis, characterized by a steady …
in varying degrees of disability. Progressive multiple sclerosis, characterized by a steady …
The CALIPR framework for highly accelerated myelin water imaging with improved precision and sensitivity
Quantitative magnetic resonance imaging (MRI) techniques are powerful tools for the study
of human tissue, but, in practice, their utility has been limited by lengthy acquisition times …
of human tissue, but, in practice, their utility has been limited by lengthy acquisition times …
[HTML][HTML] From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions
Focal lesions in both white and gray matter are characteristic of multiple sclerosis (MS).
Histopathological studies have helped define the main underlying pathological processes …
Histopathological studies have helped define the main underlying pathological processes …