To fulfill the task of gas exchange, the lung possesses a huge inner surface and a tree-like
system of conducting airways ventilating the gas exchange area. During lung development …

The respiratory system, including the peripheral lungs, large airways and trachea, is one of
the most recently evolved adaptations to terrestrial life. To support the exchange of …

Programs defining tissue-resident macrophage identity depend on local environmental
cues. For alveolar macrophages (AMs), these signals are provided by immune and …

The embryonic mouse lung is a widely used substitute for human lung development. For
example, attempts to differentiate human pluripotent stem cells to lung epithelium rely on …

Alveologenesis is the culmination of lung development and involves the correct temporal
and spatial signals to generate the delicate gas exchange interface required for respiration …

Recent studies have revealed biologically significant differences between human and
mouse lung development, and have reported new in vitro systems that allow experimental …

The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas
of the developing lung (LungMAP) to serve as a research resource and public education …

Tuft cells—rare solitary chemosensory cells in mucosal epithelia—are undergoing intense
scientific scrutiny fueled by recent discovery of unsuspected connections to type 2 immunity …

During the stepwise specification and differentiation of tissue-specific multipotent
progenitors, lineage-specific transcriptional networks are activated or repressed to …