Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Gap junctions play an important role in brain physiology. They synchronize neuronal activity
and connect glial cells participating in the regulation of brain metabolism and homeostasis …

The appearance of multicellular organisms imposed the development of several
mechanisms for cell-to-cell communication, whereby different types of cells coordinate their …

The advent of multicellular organisms, some 800 million years ago, necessitated the
development of mechanisms for cell-to-cell synchronization and for the spread of signals …

Although alkaline pH is known to trigger Ca2+ influx in diverse cells, no pH-sensitive Ca2+
channel has been identified. Here, we report that extracellular alkalinization induces …

This review gives an overview of connexin expression in glial cells of the central nervous
system, the different modes of connexin action, including gap junctional channels and …

The central nervous system (CNS) is composed of a highly heterogeneous population of
cells. Dynamic interactions between different compartments (neuronal, glial, and vascular …

Previous studies have documented that the insulin-producing β-cells of laboratory rodents
are coupled by gap junction channels made solely of the connexin36 (Cx36) protein, and …

Skin lesions are common events and we have evolved to rapidly heal them in order to
maintain homeostasis and prevent infection and sepsis. Most acute wounds heal without …