Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …

A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized and
screened in vitro as potential antimicrobials. Almost all the compounds showed antifungal …

Cadmium (Cd) toxicity poses a significant threat to cellular health, leading to oxidative stress
and cell damage. Antioxidant agents, particularly those of natural origin, have been studied …

In pharmaceutical science and drug design the versatility of the pyrrolidine scaffold relating
to spatial arrangement, synthetic accessibility and pharmacological profile is a largely …

Melatonin (N-acetyl-5-methoxytryptamine) is widely known as “the darkness hormone”. It is a
major chronobiological regulator involved in circadian phasing and sleep-wake cycle in …

Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …

Optically active α-aryloxycarboxylic acids and their derivatives are important functional
molecules. Disclosed here is a carbene-catalyzed dynamic kinetic resolution and …

The various physiological actions of the neurohormone melatonin are mediated mainly by
two G-protein-coupled MT1 and MT2 receptors. The melatoninergic drugs on the market …