A review on novel synthesis approaches and biological activities of 1, 2, 4-oxadiazole and 1, 3, 4-oxadiazole tailored compounds
T Chaudhary, PK Upadhyay - Current Organic Synthesis, 2022 - ingentaconnect.com
Rational design and synthesis of novel compounds with both effectivity and safety properties
have always been a formidable task in the development of drugs. Oxadiazoles are …
have always been a formidable task in the development of drugs. Oxadiazoles are …
Emodin alleviates chronic constriction injury-induced neuropathic pain and inflammation via modulating PPAR-gamma pathway
Neuropathic pain has been characterized as chronic pain resulting from pathological
damage to the sensorimotor system. Because of its complex nature, it remains refractory to …
damage to the sensorimotor system. Because of its complex nature, it remains refractory to …
STING contributes to cancer-induced bone pain by promoting M1 polarization of microglia in the medial prefrontal cortex
X Zhang, X Li, W Wang, Y Zhang, Z Gong, Y Peng… - Cancers, 2022 - mdpi.com
Simple Summary Cancer-induced bone pain commonly occurs in patients with bone tumors
or bone metastases, and in recent years, central nervous system hyperalgesia has received …
or bone metastases, and in recent years, central nervous system hyperalgesia has received …
Investigation of natural compounds for therapeutic potential in streptozotocin-induced diabetic neuroinflammation and neuropathic pain
Diabetic neuropathy (DN) is a serious microvascular complication of diabetes mellitus (DM)
that impacts the nervous system. Several risk factors are involved in the progression and …
that impacts the nervous system. Several risk factors are involved in the progression and …
The nephroprotective potential of selected synthetic compound against gentamicin induced nephrotoxicity
Background Nephrotoxicity, the rapid impairment of kidney function caused by harmful drugs
and chemicals, affects about 20% of cases and is projected to become a leading cause of …
and chemicals, affects about 20% of cases and is projected to become a leading cause of …
Cytotoxic Evaluation, Molecular Docking, and 2D‐QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents
The diverse pharmacological role of dihydropyrimidinone scaffold has made it to be an
interesting drug target. Because of the high incidence and mortality rate of breast cancer …
interesting drug target. Because of the high incidence and mortality rate of breast cancer …
Investigation of 1, 3, 4 oxadiazole derivative in PTZ-induced neurodegeneration: a simulation and molecular approach
Objective The study investigated the effect 5-[(naphthalen-2-yloxy) methyl]-1, 3, 4-
oxadiaszole2-thiol (B3) in animal model of acute epileptic shock. Methods The …
oxadiaszole2-thiol (B3) in animal model of acute epileptic shock. Methods The …
Pharmacological investigation of natural compounds for therapeutic potential in neuropathic pain
The present research is based on the investigation of post treatment naturally occurring
compounds berbamine (BBM), bergapten (BRG) and carveol (CAR) in relation to its …
compounds berbamine (BBM), bergapten (BRG) and carveol (CAR) in relation to its …
Safety assessment of novel oxadiazole derivatives in acute and sub-acute toxicity studies
Oxadiazole is a fascinating heterocyclic compound with a unique five-membered ring
structure containing nitrogen and oxygen atoms. It has garnered significant attention for its …
structure containing nitrogen and oxygen atoms. It has garnered significant attention for its …
Imperatorin, a natural furanocoumarin alleviates chronic neuropathic pain by targeting GABAergic tone in an animal model of spinal cord injury
Chronic neuropathic pain (CNP) caused by spinal cord injury (SCI) has long-term
implications, that result in functional deficit. In this study, we explored imperatorin, a natural …
implications, that result in functional deficit. In this study, we explored imperatorin, a natural …