Human leukocyte antigen super-locus: nexus of genomic supergenes, SNPs, indels, transcripts, and haplotypes
Abstract The human Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen
(HLA) super-locus is a highly polymorphic genomic region that encodes more than 140 …
(HLA) super-locus is a highly polymorphic genomic region that encodes more than 140 …
Effects of urban living environments on mental health in adults
J Xu, N Liu, E Polemiti, L Garcia-Mondragon, J Tang… - Nature medicine, 2023 - nature.com
Urban-living individuals are exposed to many environmental factors that may combine and
interact to influence mental health. While individual factors of an urban environment have …
interact to influence mental health. While individual factors of an urban environment have …
[HTML][HTML] Chromosomal inversion polymorphisms shape human brain morphology
The impact of chromosomal inversions on human brain morphology remains underexplored.
We studied 35 common inversions classified from genotypes of 33,018 adults with European …
We studied 35 common inversions classified from genotypes of 33,018 adults with European …
Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases
C Pedicone, SA Weitzman, AE Renton… - Molecular …, 2024 - Springer
A~ 1 Mb inversion polymorphism exists within the 17q21. 31 locus of the human genome as
direct (H1) and inverted (H2) haplotype clades. This inversion region demonstrates high …
direct (H1) and inverted (H2) haplotype clades. This inversion region demonstrates high …
Genomic hotspots of chromosome rearrangements explain conserved synteny despite high rates of chromosome evolution in a holocentric lineage
Holocentric organisms, unlike typical monocentric organisms, have kinetochore activity
distributed along almost the whole length of the chromosome. Because of this, chromosome …
distributed along almost the whole length of the chromosome. Because of this, chromosome …
Impact of population structure in the estimation of recent historical effective population size by the software GONE
I Novo, P Ordás, N Moraga, E Santiago… - Genetics Selection …, 2023 - Springer
Background Effective population size (N e) is a crucial parameter in conservation genetics
and animal breeding. A recent method, implemented by the software GONE, has been …
and animal breeding. A recent method, implemented by the software GONE, has been …
Genomic architecture of supergenes: connecting form and function
Supergenes are tightly linked sets of loci that are inherited together and control complex
phenotypes. While classical supergenes—governing traits such as wing patterns in …
phenotypes. While classical supergenes—governing traits such as wing patterns in …
Identifying genetic variants associated with chromatin looping and genome function
S Bhattacharyya, F Ay - Nature Communications, 2024 - nature.com
Here we present a comprehensive HiChIP dataset on naïve CD4 T cells (nCD4) from 30
donors and identify QTLs that associate with genotype-dependent and/or allele-specific …
donors and identify QTLs that associate with genotype-dependent and/or allele-specific …
Discovering genetic mechanisms underlying the co-occurrence of Parkinson's disease and non-motor traits
Understanding the biological mechanisms that underlie the non-motor symptoms of
Parkinson's disease (PD) requires comprehensive frameworks that unravel the complex …
Parkinson's disease (PD) requires comprehensive frameworks that unravel the complex …
The shared genetic architecture and evolution of human language and musical rhythm
This study aimed to test theoretical predictions over biological underpinnings of previously
documented phenotypic correlations between human language-related and musical rhythm …
documented phenotypic correlations between human language-related and musical rhythm …