Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Lidocaine block of cardiac sodium channels was studied in voltage-clamped rabbit purkinje
fibers at drug concentrations ranging from 1 mM down to effective antiarrhythmic doses (5 …

Torsades DE POINTES is the captivat-ing expression coined by Dessertenne'and adopted
world-wide to describe the ventricular tachyarrhythmias that occur in the setting of QT …

The epidemiological studies of Kromann and Green 1 on the low mortality rate of Greenland
Inuits from ischemic heart disease led to the suggestion by Bang et al 2 that despite the high …

Rationale: Although the sodium channel locus SCN10A has been implicated by genome-
wide association studies as a modulator of cardiac electrophysiology, the role of its gene …

The transmembrane sodium gradient is essential for both excitability of the cardiac cell and
the regulation of the cytoplasmic concentrations of Ca and protons. In addition, movements …

Early afterdepolarizations (EADs) are one mechanism proposed to cause certain cardiac
arrhythmias. We studied the effect of the Ca2+ channel agonist Bay K 8644 (1 x 10 (-8) to 5 x …