Intestinal mucin-type O-glycans: the major players in the host-bacteria-rotavirus interactions

SA Raev, JO Amimo, LJ Saif, AN Vlasova - Gut Microbes, 2023 - Taylor & Francis
Rotavirus (RV) causes severe diarrhea in young children and animals worldwide. Several
glycans terminating in sialic acids (SAs) and histo-blood group antigens (HBGAs) on …

Differential transcriptome response following infection of porcine ileal enteroids with species A and C rotaviruses

SA Raev, M Raque, MK Kick, LJ Saif, AN Vlasova - Virology Journal, 2023 - Springer
Abstract Background Rotavirus C (RVC) is the major causative agent of acute gastroenteritis
in suckling piglets, while most RVAs mostly affect weaned animals. Besides, while most RVA …

Advances in porcine respiratory and intestinal organoids: status and potential application for virus infections

C Liu, X Dong, P Liu, X Lin - One Health Advances, 2024 - Springer
The respiratory tract and digestive tract serve as the gateway between the host and the
environment, playing an important role in protecting against viral infections. Diseases …

PoRVA G9P [23] and G5P [7] infections differentially promote PEDV replication by reprogramming glutamine metabolism

H Liu, H Tian, P Hao, H Du, K Wang, Y Qiu, X Yin… - PLoS …, 2024 - journals.plos.org
PoRVA and PEDV coinfections are extremely common in clinical practice. Although
coinfections of PoRVA and PEDV are known to result in increased mortality, the underlying …

Development and characterization of segment-specific enteroids from the pig small intestine in Matrigel and transwell inserts: insights into susceptibility to porcine …

L Yen, RK Nelli, NC Twu, JC Mora-Díaz… - Frontiers in …, 2024 - frontiersin.org
Introduction The critical early stages of infection and innate immune responses to porcine
epidemic diarrhea virus (PEDV) at the intestinal epithelium remain underexplored due to the …

Characterization of viroplasm-like structures by co-expression of NSP5 and NSP2 across rotavirus species A to J

M Lee, A Cosic, K Tobler, C Aguilar, C Fraefel… - Journal of …, 2024 - journals.asm.org
Rotaviruses (RVs) are classified into nine species, A–D and F–J, with species A being the
most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are …

Histo-Blood Group Antigen-Producing Bacterial Cocktail Reduces Rotavirus A, B, and C Infection and Disease in Gnotobiotic Piglets

SA Raev, MK Kick, M Chellis, JO Amimo, LJ Saif… - Viruses, 2024 - mdpi.com
The suboptimal performance of rotavirus (RV) vaccines in developing countries and in
animals necessitates further research on the development of novel therapeutics and control …

[HTML][HTML] Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets

X Lai, A Wu, B Yu, H Yan, J Luo, P Zheng, J Yu… - Animal Nutrition, 2024 - Elsevier
Rotaviruses (RV) are a major cause of severe gastroenteritis, particularly in neonatal piglets.
Despite the availability of effective vaccines, the development of antiviral therapies for RV …

[HTML][HTML] 14th International dsRNA Virus Symposium, Banff, Alberta, Canada, 10-14 October 2022

U Desselberger - Virus Research, 2023 - Elsevier
Abstract This triennial International dsRNA Virus Symposium covered original data which
have accrued during the most recent five years. In detail, the genomic diversity of these …

Host Cell Response to Rotavirus Infection with Emphasis on Virus–Glycan Interactions, Cholesterol Metabolism, and Innate Immunity

M Raque, SA Raev, Y Guo, MK Kick, LJ Saif… - Viruses, 2023 - mdpi.com
Although rotavirus A (RVA) is the primary cause of acute viral gastroenteritis in children and
young animals, mechanisms of its replication and pathogenesis remain poorly understood …