Abstract Background Adverse outcome pathways (AOPs) are conceptual frameworks that
organize knowledge about biological interactions and toxicity mechanisms. They present a …

Various studies have shown that the reproductive organs are highly sensitive to toxic
elements found in the environment. Due to technological progress, the use of nanoparticles …

While clinical innovation has improved, cancer or malignant growth stays a genuine medical
issue and has been perceived as a significant factor in mortality and morbidity. Current work …

This study was designed to evaluate the protective potentials of chitosan nanoparticles
(ChNPs) against silver nanoparticle (AgNP)-induced reproductive toxicity in male Wister …

This study evaluated the ameliorative potential of grape seed extract (GSE) against Ehrlich
solid tumor (EST)–induced hepatic tissue alterations in mice. The control group was infused …

Methotrexate (MTX; 4‐amino‐10‐methylfolic acid) is a folic acid reductase inhibitor used to
treat autoimmune diseases and certain types of cancer. Testicular toxicity resulting from MTX …

Abstract Copper oxide nanoparticles (CuO NPs) have developed as a significant class of
nanomaterial with potential dangers to organisms and the environment in a variety of …

Breast cancer remains the most common cause of cancer deaths among women globally.
Ehrlich solid tumor (EST) is a transplantable tumor model for simulating breast cancer. This …

The real impact of nanoparticles on male fertility is evaluated after a careful analysis of the
available literature. The first part reviews animal models to understand the testicular …

Major depressive disorder and anxiety disorders are two mental diseases that are treated
with amitriptyline (AMT). AMT treatments induced liver, heart and testes toxicity; As a result …