Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the
small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat …

The platelet integrin αIIbβ3 is required for platelet aggregation. Like other integrins, αIIbβ3
resides on cell surfaces in an equilibrium between inactive and active conformations …

Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury,
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …

Platelets are anucleate blood cells, long known to be critically involved in hemostasis and
thrombosis. In addition to their role in blood clots, increasing evidence reveals significant …

Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding syndrome affecting
the megakaryocyte lineage and characterized by lack of platelet aggregation. The molecular …

In the past 2 decades, it has been appreciated that the functions of the extracellular matrix
(ECM) are not entirely structural. ECM components interact with specific adhesion receptors …

GMP-140 is an integral membrane glycoprotein found in secretory granules of platelets and
endothelial cells. After cellular activation, it is rapidly redistributed to the plasma membrane …

Adhesion of platelets to the subendothelial matrix of an injured vessel wall is an essential
step in triggering the formation of a haemostatic plug. Fibronectin, collagen and laminin are …

Enclothelial cells and activated platelets express integrin-type receptors responsible for
adhesion to fibrinogen. We have located distinct integrin-directed endothelial cell and …