An updated review on diverse range of biological activities of 1, 2, 4-triazole derivatives: Insight into structure activity relationship
Abstract Since its discovery 1, 2, 4-triazole ring has emerged as a prominent heterocyclic
scaffold in medicinal chemistry. It possesses a wide spectrum of biological activities such as …
scaffold in medicinal chemistry. It possesses a wide spectrum of biological activities such as …
Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach
NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
Synthetic and Medicinal Perspective of 1, 2, 4‐Triazole as Anticancer Agents
Cancer is still one of the leading causes of death worldwide. Many researchers are working
to design and develop heterocyclic‐based drugs with the potential to treat cancer at various …
to design and develop heterocyclic‐based drugs with the potential to treat cancer at various …
Synthesis, X-ray, DFT, Hirshfeld surface analysis, molecular docking, urease inhibition, antioxidant, cytotoxicity, DNA protection, and DNA binding properties of 5-(tert-butyl)-N-(2 …
(Tert-butyl)-N-(2, 4-dichlorophenyl)-1 H-1, 2, 4-triazol-3-amine was synthesized in four steps
starting from pivalic acid via thiourea formation followed by heterocyclization with hydrazine …
starting from pivalic acid via thiourea formation followed by heterocyclization with hydrazine …
Discovery of phenylcarbamoylazinane-1, 2, 4-triazole amides derivatives as the potential inhibitors of aldo-keto reductases (AKR1B1 & AKRB10): Potential lead …
Both members of the aldo-keto reductases (AKRs) family, AKR1B1 and AKR1B10, are over-
expressed in various type of cancer, making them potential targets for inflammation …
expressed in various type of cancer, making them potential targets for inflammation …
[HTML][HTML] Isatin-based ibuprofen and mefenamic acid Schiff base derivatives as dual inhibitors against urease and α–glucosidase: in vitro, in silico and cytotoxicity …
S Daud, M Saadullah, M Fakhar-e-Alam… - Journal of Saudi …, 2024 - Elsevier
Abstract α-Glucosidase and urease inhibitors have emerged as crucial for developing
therapeutic drugs targeting diabetes and gastrointestinal disorders. This study reports on …
therapeutic drugs targeting diabetes and gastrointestinal disorders. This study reports on …
Synthesis of tetracyclic spirooxindolepyrrolidine-engrafted hydantoin scaffolds: crystallographic analysis, molecular docking studies and evaluation of their …
A Toumi, FIA Abdella, S Boudriga, TYA Alanazi… - Molecules, 2023 - mdpi.com
In a sustained search for novel potential drug candidates with multispectrum therapeutic
application, a series of novel spirooxindoles was designed and synthesized via …
application, a series of novel spirooxindoles was designed and synthesized via …
4-Chlorophenyl-N-furfuryl-1,2,4-triazole Methylacetamides as Significant 15-Lipoxygenase Inhibitors: an Efficient Approach for Finding Lead Anti-inflammatory …
Lipoxygenases (LOXs) are a class of enzymes that catalyze the production of pro-
inflammatory mediators, such as leukotrienes and lipoxins, via an arachidonic acid cascade …
inflammatory mediators, such as leukotrienes and lipoxins, via an arachidonic acid cascade …
Assessing p-tolyloxy-1, 3, 4-oxadiazole acetamides as lipoxygenase inhibitors assisted by in vitro and in silico studies
The underlying correlation between the inflammation, innate immunity and cancer is
extensively familiar and linked through a process mediated by three enzymes; …
extensively familiar and linked through a process mediated by three enzymes; …
Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1, 2, 4-triazole
Y Sameliuk, A Kaplaushenko… - … University Journal of …, 2022 - dergipark.org.tr
The purpose of this literature review was to systematize data from studies of the biological
activity of 1, 2, 4-triazole derivatives with substituents in positions 4 and 5. The authors set …
activity of 1, 2, 4-triazole derivatives with substituents in positions 4 and 5. The authors set …