[HTML][HTML] Modelling the mechanical properties of cardiac muscle

PJ Hunter, AD McCulloch, H Ter Keurs - Progress in biophysics and …, 1998 - Elsevier
A model of passive and active cardiac muscle mechanics is presented, suitable for use in
continuum mechanics models of the whole heart. The model is based on an extensive …

Myofilament length dependent activation

PP de Tombe, RD Mateja, K Tachampa, YA Mou… - Journal of molecular and …, 2010 - Elsevier
The Frank–Starling law of the heart describes the interrelationship between end-diastolic
volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat …

Genetic and functional insights into the fractal structure of the heart

HV Meyer, TJW Dawes, M Serrani, W Bai, P Tokarczuk… - Nature, 2020 - nature.com
The inner surfaces of the human heart are covered by a complex network of muscular
strands that is thought to be a remnant of embryonic development,. The function of these …

[图书][B] Excitation-contraction coupling and cardiac contractile force

D Bers - 2001 - books.google.com
How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators

M Strocchi, S Longobardi, CM Augustin… - PLoS Computational …, 2023 - journals.plos.org
Cardiac pump function arises from a series of highly orchestrated events across multiple
scales. Computational electromechanics can encode these events in physics-constrained …

Cardiac energy metabolism homeostasis: role of cytosolic calcium

RS Balaban - Journal of molecular and cellular cardiology, 2002 - Elsevier
RS Balaban. Cardiac Energy Metabolism Homeotasis: Role of Cytosolic Calcium. Journal of
Molecular and Cellular Cardiology (2002) 34, 1259–1271. The heart is capable of …

Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients

H Wu, H Yang, JW Rhee, JZ Zhang… - European heart …, 2019 - academic.oup.com
Aims Diastolic dysfunction (DD) is common among hypertrophic cardiomyopathy (HCM)
patients, causing major morbidity and mortality. However, its cellular mechanisms are not …

Calcium and arrhythmogenesis

HEDJ Ter Keurs, PA Boyden - Physiological reviews, 2007 - journals.physiology.org
Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

[HTML][HTML] The role of Ca2+ signaling in the coordination of mitochondrial ATP production with cardiac work

RS Balaban - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2009 - Elsevier
The heart is capable of balancing the rate of mitochondrial ATP production with utilization
continuously over a wide range of activity. This results in a constant phosphorylation …

[图书][B] Biomedical engineering fundamentals

JD Bronzino, DR Peterson - 2014 - books.google.com
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook,
Fourth Edition, sets the standard against which all other references of this nature are …