Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

Highlights•Expression of reference and variant human genes in flies permit functional
testing.•Innovative genetic strategies in flies drive discovery of disease associated …

Systemic inhibition of neuropathy target esterase (NTE) with certain organophosphorus (OP)
compounds produces OP compound-induced delayed neurotoxicity (OPIDN), a distal …

The development of endurance exercise paradigms in Drosophila has facilitated study of
genetic factors that control individual response to exercise. Recent work in Drosophila has …

Patatin-like phospholipase domain-containing protein 6 (PNPLA6), originally called
Neuropathy Target Esterase (NTE), belongs to a family of hydrolases with at least eight …

Progressive neurodegenerative diseases like Alzheimer's disease (AD) or Parkinson's
disease (PD) are an increasing threat to human health worldwide. Although mammalian …

Various neurodegenerative disorders are associated with human NTE/PNPLA6 dysfunction.
Mechanisms of neuropathogenesis in these diseases are far from clearly elucidated …

Abstract Mutations in Drosophila Swiss cheese (SWS) gene or its vertebrate orthologue
neuropathy target esterase (NTE) lead to progressive neuronal degeneration in flies and …

Simple Summary Biological evolution implies fitness of newly evolved organisms that have
inherent adaptive traits because of mutations in genes. However, most mutations are …

The use of the Drosophila model for studying the broad beneficial effects of exercise training
has grown over the past decade. As work using Drosophila as an exercise model becomes …