In recent years, RNA has emerged as a multifaceted biomolecule that is involved in virtually
every function of the cell and is critical for human health. This has led to a substantial …

With the advent of novel bioorthogonal reactions and “click” chemistry, an increasing
number of strategies for the single labelling of proteins and oligonucleotides have emerged …

New discoveries in RNA biology underscore a need for chemical tools to clarify their roles in
pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor …

Labeled RNA becomes increasingly important for molecular diagnostics and biophysical
studies on RNA with its diverse interaction partners, which range from small metabolites to …

Functional microRNAs (miRNAs) are produced from both arms of their precursors (pre-
miRNAs). Their abundances vary in context-dependent fashion spatiotemporarily and there …

A simple and efficient microwave-assisted synthesis of asymmetric pentamethine cyanine
dyes with various functional groups was developed, which allows high-yielding results. The …

The nascent peptide exit tunnel has recently been identified as a functional region of
ribosomes contributing to translation regulation and co-translational protein folding …

Erythropoietic protoporphyria (EPP) is a rare genetic disease in which patients experience
acute phototoxic reactions after sunlight exposure. It is caused by a deficiency in …

We present a method to synthesize mRNAs from synthetic DNA templates that produce
biologically active proteins. To illustrate utility, we constructed five unique synthetic DNA …

MicroRNAs (miRNAs) originate from stem-loop-containing precursors (pre-miRNAs, pri-
miRNAs) and mature by means of the Drosha and Dicer endonucleases and their …