Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very
heterogeneous biological and clinical behavior. The last decade has been remarkably …

Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic …

Patients with chronic lymphocytic leukemia (CLL) progressing on ibrutinib constitute an
unmet need. Though Bruton tyrosine kinase (BTK) and PLCG2 mutations are associated …

Acquired somatic mutations are crucial for the development of most cancers. We performed
a comprehensive comparative analysis of the mutational landscapes and their correlation …

More than 50 subtypes of B-cell non-Hodgkin lymphoma (B-NHL) are recognized in the most
recent World Health Organization classification of 2016. The current treatment paradigm …

Normal cell counterparts of solid and myeloid tumors accumulate mutations years before
disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain …

Patients with chronic lymphocytic leukemia can be divided into three categories: those who
are minimally affected by the problem, often never requiring therapy; those that initially …

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western
countries and is characterized by the clonal expansion of mature CD5+ B cells. There have …

The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …