CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells

T Bexte, N Albinger, A Al Ajami, P Wendel… - Nature …, 2024 - nature.com
Chimeric antigen receptor (CAR)-modified natural killer (NK) cells show antileukemic activity
against acute myeloid leukemia (AML) in vivo. However, NK cell-mediated tumor killing is …

A structural, genetic and clinical comparison of CAR-T cells and CAR-NK cells: companions or competitors?

AE Andrea, A Chiron, G Sarrabayrouse… - Frontiers in …, 2024 - frontiersin.org
In recent years, following the groundbreaking achievements of chimeric antigen receptor
(CAR) T cell therapy in hematological cancers, and advancements in cell engineering …

Non-viral vectors for chimeric antigen receptor immunotherapy

US Tretbar, JG Rurik, EH Rustad, D Sürün… - Nature Reviews …, 2024 - nature.com
Chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable efficacy in
haematological malignancies. However, although viral vector-based methods are effective …

[HTML][HTML] Current Non-Viral-Based Strategies to Manufacture CAR-T Cells

L Gehrke, VDR Gonçalves, D Andrae, T Rasko… - International journal of …, 2024 - mdpi.com
The successful application of CAR-T cells in the treatment of hematologic malignancies has
fundamentally changed cancer therapy. With increasing numbers of registered CAR-T cell …

Empowering virus-free CAR immune cell therapies

T Bexte, E Ullrich - Molecular Therapy, 2024 - cell.com
Immune cell therapies with chimeric antigen receptor (CAR)-T and natural killer (NK) cells
have demonstrated groundbreaking therapeutic effects in hematological malignancies in the …