Making choices: DNA replication fork recovery mechanisms
CM Kondratick, MT Washington, M Spies - Seminars in cell & …, 2021 - Elsevier
DNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …
DNA damage bypass pathways and their effect on mutagenesis in yeast
What is the origin of mutations? In contrast to the naïve notion that mutations are unfortunate
accidents, genetic research in microorganisms has demonstrated that most mutations are …
accidents, genetic research in microorganisms has demonstrated that most mutations are …
Carbon catabolite repression in yeast is not limited to glucose
K Simpson-Lavy, M Kupiec - Scientific reports, 2019 - nature.com
Cells adapt their gene expression and their metabolism in response to a changing
environment. Glucose represses expression of genes involved in the catabolism of other …
environment. Glucose represses expression of genes involved in the catabolism of other …
Spatial regulation of DNA damage tolerance protein Rad5 interconnects genome stability maintenance and proteostasis networks
CP Lehmann, P González-Fernández… - Nucleic Acids …, 2024 - academic.oup.com
The Rad5/HLTF protein has a central role in the tolerance to DNA damage by mediating an
error-free mode of bypassing unrepaired DNA lesions, and is therefore critical for the …
error-free mode of bypassing unrepaired DNA lesions, and is therefore critical for the …
Rad5 recruits error-prone DNA polymerases for mutagenic repair of ssDNA gaps on undamaged templates
Post-replication repair (PRR) allows tolerance of chemical-and UV-induced DNA base
lesions in both an error-free and an error-prone manner. In classical PRR, PCNA …
lesions in both an error-free and an error-prone manner. In classical PRR, PCNA …
Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway
Y Masuda, S Mitsuyuki, R Kanao, A Hishiki… - Nucleic acids …, 2018 - academic.oup.com
DNA-damage tolerance protects cells via at least two sub-pathways regulated by
proliferating cell nuclear antigen (PCNA) ubiquitination in eukaryotes: translesion DNA …
proliferating cell nuclear antigen (PCNA) ubiquitination in eukaryotes: translesion DNA …
Post-translational modifications of PCNA: guiding for the best DNA damage tolerance choice
G Bellí, N Colomina, L Castells-Roca, NP Lorite - Journal of Fungi, 2022 - mdpi.com
The sliding clamp PCNA is a multifunctional homotrimer mainly linked to DNA replication.
During this process, cells must ensure an accurate and complete genome replication when …
During this process, cells must ensure an accurate and complete genome replication when …
Access to pcna by srs2 and elg1 controls the choice between alternative repair pathways in saccharomyces cerevisiae
During DNA replication, stalling can occur when the replicative DNA polymerases encounter
lesions or hard-to replicate regions. Under these circumstances, the processivity factor …
lesions or hard-to replicate regions. Under these circumstances, the processivity factor …
Prevention of unwanted recombination at damaged replication forks
CP Lehmann, A Jiménez-Martín, D Branzei, JA Tercero - Current Genetics, 2020 - Springer
Homologous recombination is essential for the maintenance of genome integrity but must be
strictly controlled to avoid dangerous outcomes that produce the opposite effect, genomic …
strictly controlled to avoid dangerous outcomes that produce the opposite effect, genomic …
Post-replication repair: Rad5/HLTF regulation, activity on undamaged templates, and relationship to cancer
The eukaryotic post-replication repair (PRR) pathway allows completion of DNA replication
when replication forks encounter lesions on the DNA template and are mediated by post …
when replication forks encounter lesions on the DNA template and are mediated by post …