Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an
important target for nociceptive regulation at the spinal level. However, little is known about …

Physiologic sites for inhaled anesthetics are presumed to be cavities within transmembrane
4‐α‐helix bundles of neurotransmitter receptors, but confirmation of binding and structural …

The cellular membrane constitutes the first element that encounters a wide variety of
molecular species to which a cell might be exposed. Hosting a large number of structurally …

While small molecules have been used to induce anesthesia in a clinical setting for well
over a century, a detailed understanding of the molecular mechanism remains elusive. In …

Bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC) is activated to
cation permeation upon lowering the solution pH. Its function can be modulated by …

The structures and intermolecular interactions in the halogen bonded complexes of
anaesthetics (chloroform, halothane, enflurane and isoflurane) with formaldehyde were …

Cys-loop receptors are molecular targets of general anesthetics, but the knowledge of
anesthetic binding to these proteins remains limited. Here we investigate anesthetic binding …

The complex of halothane (CHClBrCF3) and dimethyl ether has been investigated
experimentally in solutions of liquid krypton using infrared spectroscopy and theoretically …

Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an
important target for nociceptive regulation at the spinal level. However, little is known about …

The neuronal α4β2 nicotinic acetylcholine receptor (nAChR) is a target for general
anesthetics. Currently available experimental structural information is inadequate to …