Voltage‐gated sodium channels at 60: structure, function and pathophysiology

WA Catterall - The Journal of physiology, 2012 - Wiley Online Library
Voltage‐gated sodium channels initiate action potentials in nerve, muscle and other
excitable cells. The sodium current that initiates the nerve action potential was discovered by …

Ion channel voltage sensors: structure, function, and pathophysiology

WA Catterall - Neuron, 2010 - cell.com
Voltage-gated ion channels generate electrical signals in species from bacteria to man.
Their voltage-sensing modules are responsible for initiation of action potentials and graded …

Resting-state structure and gating mechanism of a voltage-gated sodium channel

G Wisedchaisri, L Tonggu, E McCord, TMG El-Din… - Cell, 2019 - cell.com
Voltage-gated sodium (Na V) channels initiate action potentials in nerve, muscle, and other
electrically excitable cells. The structural basis of voltage gating is uncertain because the …

The RosettaDock server for local protein–protein docking

S Lyskov, JJ Gray - Nucleic acids research, 2008 - academic.oup.com
Abstract The RosettaDock server (http://rosettadock. graylab. jhu. edu) identifies low-energy
conformations of a protein–protein interaction near a given starting configuration by …

Voltage-gated ion channels and gating modifier toxins

WA Catterall, S Cestèle, V Yarov-Yarovoy, HY Frank… - Toxicon, 2007 - Elsevier
Voltage-gated sodium, calcium, and potassium channels generate electrical signals
required for action potential generation and conduction and are the molecular targets for a …

Scorpion venom components that affect ion-channels function

V Quintero-Hernández, JM Jiménez-Vargas… - Toxicon, 2013 - Elsevier
The number and types of venom components that affect ion-channel function are reviewed.
These are the most important venom components responsible for human intoxication …

The hitchhiker's guide to the voltage-gated sodium channel galaxy

CA Ahern, J Payandeh, F Bosmans… - Journal of General …, 2016 - rupress.org
Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …

Neurotoxins and their binding areas on voltage-gated sodium channels

M Stevens, S Peigneur, J Tytgat - Frontiers in pharmacology, 2011 - frontiersin.org
Voltage-gated sodium channels (VGSCs) are large transmembrane proteins that conduct
sodium ions across the membrane and by doing so they generate signals of communication …

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

D Jiang, L Tonggu, TM Gamal El-Din, R Banh… - Nature …, 2021 - nature.com
Voltage-gated sodium (NaV) channels initiate action potentials in excitable cells, and their
function is altered by potent gating-modifier toxins. The α-toxin LqhIII from the deathstalker …

Structural basis for gating charge movement in the voltage sensor of a sodium channel

V Yarov-Yarovoy, PG DeCaen… - Proceedings of the …, 2012 - National Acad Sciences
Voltage-dependent gating of ion channels is essential for electrical signaling in excitable
cells, but the structural basis for voltage sensor function is unknown. We constructed high …