Mesenchymal stem cell therapy in diabetes mellitus: progress and challenges

N El-Badri, MA Ghoneim - Journal of nucleic acids, 2013 - Wiley Online Library
Advanced type 2 diabetes mellitus is associated with significant morbidity and mortality due
to cardiovascular, nervous, and renal complications. Attempts to cure diabetes mellitus using …

In vitro generation of transplantable insulin-producing cells from canine adipose-derived mesenchymal stem cells

Q Dang Le, W Rodprasert, S Kuncorojakti… - Scientific reports, 2022 - nature.com
Canine mesenchymal stem cells (cMSCs) have potential applications for regenerative
therapy, including the generation of insulin-producing cells (IPCs) for studying and treating …

Generation of insulin‐producing cells from human adipose‐derived mesenchymal stem cells on PVA scaffold by optimized differentiation protocol

SE Enderami, M Soleimani, Y Mortazavi… - Journal of cellular …, 2018 - Wiley Online Library
The studies have been done on patient‐specific human adipose‐derived from mesenchymal
stem cells (hADSCs) like a series of autologous growth factors and nanofibrous scaffolds …

Three-dimensional differentiation of adipose-derived mesenchymal stem cells into insulin-producing cells

L Khorsandi, A Khodadadi, F Nejad-Dehbashi… - Cell and tissue …, 2015 - Springer
The aim of this study is to evaluate the collagen/hyaluronic acid (Col/HA) scaffold effect on
the differentiation of insulin-producing cells (IPCs) from adipose-derived mesenchymal stem …

Electrospun poly‐l‐lactic acid/polyvinyl alcohol nanofibers improved insulin‐producing cell differentiation potential of human adipose‐derived mesenchymal stem …

M Ojaghi, F Soleimanifar, A Kazemi… - Journal of cellular …, 2019 - Wiley Online Library
Combination of adipose‐derived mesenchymal stem cells (ADSCs) and synthetic materials
in terms of pancreatic tissue engineering can be considered as a treatment of diabetes. This …

Exendin-4 enhances the differentiation of Wharton's jelly mesenchymal stem cells into insulin-producing cells through activation of various β-cell markers

DH Kassem, MM Kamal, AELG El-Kholy… - Stem Cell Research & …, 2016 - Springer
Background Diabetes mellitus is a devastating metabolic disease. Generation of insulin-
producing cells (IPCs) from stem cells, especially from Wharton's jelly mesenchymal stem …

Generation of Insulin‐Producing Cells from Human Bone Marrow‐Derived Mesenchymal Stem Cells: Comparison of Three Differentiation Protocols

MM Gabr, MM Zakaria, AF Refaie… - BioMed research …, 2014 - Wiley Online Library
Introduction. Many protocols were utilized for directed differentiation of mesenchymal stem
cells (MSCs) to form insulin‐producing cells (IPCs). We compared the relative efficiency of …

Direct differentiation of bone marrow mononucleated cells into insulin-producing cells using 4 specific soluble factors

SA Lee, S Kim, SY Kim, JY Park, J Nan… - Stem Cells …, 2023 - academic.oup.com
Bone marrow-derived stem cells are self-renewing and multipotent adult stem cells that
differentiate into several types of cells. Here, we investigated a unique combination of 4 …

Microporous polymer scaffolds for the transplantation of embryonic stem cell derived pancreatic progenitors to a clinically translatable site for the treatment of type I …

T Kasputis, D Clough, F Noto, K Rychel… - ACS biomaterials …, 2018 - ACS Publications
Type I diabetes mellitus, which affects an estimated 1.5 million Americans, is caused by
autoimmune destruction of the pancreatic β-cells that results in the need for life-long insulin …

Investigation of the effect of pancreatic decellularized matrix on encapsulated Islets of Langerhans with mesenchymal stem cells

A Okcu, Y Yazir, T Şimşek, S Mert, G Duruksu, A Öztürk… - Tissue and Cell, 2023 - Elsevier
Objective In this study, it was aimed to provide a therapeutic approach for T1DM by
encapsulating the pancreatic islets with mesenchymal stem cells and decellularized …