Cardiovascular disease is a leading cause of morbidity and mortality in individuals with
Down syndrome. Congenital heart disease is the most common cardiovascular condition in …

People with Down syndrome show signs of chronic immune dysregulation, including a
higher prevalence of autoimmune disorders, increased rates of hospitalization during …

Targeted neonatal echocardiography (TNE) involves the use of comprehensive
echocardiography to appraise cardiovascular physiology and neonatal hemodynamics to …

Aim To review multiorgan involvement and management in children with Down syndrome
(DS). Methods A literature review of articles from 1980 to 2019 using the MEDLINE interface …

Persistent pulmonary hypertension of the newborn (PPHN) is a significant clinical problem
characterized by refractory and severe hypoxemia secondary to elevated pulmonary …

Pneumonia and respiratory infections impact infants and children with Down syndrome;
pneumonia is a leading cause of mortality in adults with Down syndrome. We aimed to …

BACKGROUND: Recent advances in medical care have increased life expectancy and
improved the quality of life for people with Down syndrome (DS). These advances are the …

Objective To describe the prevalence of pulmonary arterial hypertension (PAH)-associated
gene mutations, and other genetic characteristics in a national cohort of children with PAH …

Individuals with Down syndrome (DS) have an increased risk of developing pulmonary
hypertension (PH). In this review, we explore the epidemiology and clinical characteristics of …

Down syndrome arises from chromosomal non-disjunction during gametogenesis, resulting
in an additional chromosome. This anomaly presents with intellectual impairment, growth …