Accelerated Alzheimer's Aβ-42 secondary nucleation chronologically visualized on fibril surfaces
Protein fibril surfaces tend to generate toxic oligomers catalytically. To date, efforts to study
the accelerated aggregation steps involved with Alzheimer's disease–linked amyloid-β (Aβ) …
the accelerated aggregation steps involved with Alzheimer's disease–linked amyloid-β (Aβ) …
From experimental studies to computational approaches: recent trends in designing novel therapeutics for amyloidogenesis
Amyloidosis is a condition marked by misfolded proteins that build up in tissues and
eventually destroy organs. It has been connected to a number of fatal illnesses, including …
eventually destroy organs. It has been connected to a number of fatal illnesses, including …
The double-layered structure of amyloid-β assemblage on GM1-containing membranes catalytically promotes fibrillization
Alzheimer's disease (AD) is associated with progressive accumulation of amyloid-β (Aβ)
cross-β fibrils in the brain. Aβ species tightly associated with GM1 ganglioside, a …
cross-β fibrils in the brain. Aβ species tightly associated with GM1 ganglioside, a …
Growth kinetics of amyloid-like fibrils: An integrated atomistic simulation and continuum theory approach
Amyloid fibrils have long been associated with many neurodegenerative diseases. The
conventional picture of the formation and proliferation of fibrils from unfolded proteins …
conventional picture of the formation and proliferation of fibrils from unfolded proteins …
Deciphering the Cofilin Oligomers via Intermolecular Disulfide Bond Formation: A Coarse-Grained Molecular Dynamics Approach to Understanding Cofilin's …
Cofilin, a key actin-binding protein, orchestrates the dynamics of the actomyosin network
through its actin-severing activity and by promoting the recycling of actin monomers. Recent …
through its actin-severing activity and by promoting the recycling of actin monomers. Recent …
Exploring Abeta42 Monomer Diffusion Dynamics on Fibril Surfaces through Molecular Simulations
YW Ma, GF Wang, HY Chen, MY Tsai - bioRxiv, 2024 - biorxiv.org
This study provides critical insights into the role of surface-mediated secondary processes in
Alzheimer's disease, particularly regarding the aggregation of Abeta42 peptides. Employing …
Alzheimer's disease, particularly regarding the aggregation of Abeta42 peptides. Employing …
BUILDING A MODEL TO SIMULATE PROTEIN AGGREGATION AT ATOMISTIC DETAIL.
E Scalone - 2023 - air.unimi.it
The project I have been focusing for the last three years was the development of a
computational method to simulate protein aggregation into amyloids. As further described …
computational method to simulate protein aggregation into amyloids. As further described …