Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

Abstract SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …

Coronavirus replication is associated with the remodeling of cellular membranes, resulting
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …

Positive single-strand RNA (+ RNA) viruses can remodel host cell membranes to induce a
replication organelle (RO) isolating the replication of their genome from innate immunity …

SARS-CoV-2, the causative agent of COVID-19 encodes at least 16 nonstructural proteins of
variably understood function. Nsp3, the largest nonstructural protein contains several …

β-coronaviruses reshape host cell endomembranes to form double-membrane vesicles
(DMVs) for genome replication and transcription. Ectopically expressed viral nonstructural …

Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

ER-phagy is a form of autophagy that is mediated by ER-phagy receptors and selectively
degrades endoplasmic reticulum (ER). Coronaviruses have been shown to use the ER as a …