Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal
neurodegenerative disease. Although the pathogenesis of ALS remains unclear, increasing …

Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's
disease (PD) are a heterogeneous group of disorders characterized by progressive …

The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …

Elastases are a broad group of enzymes involved in the lysis of elastin, the main component
of elastic fibres. They are produced and released in the human body, mainly by neutrophils …

Introduction Cell-penetrating peptide (CPP) technologies represent an important strategy to
address drug delivery to specific intracellular compartments by covalent conjugation to …

Mitochondria are vital subcellular organelles that generate most cellular chemical energy,
regulate cell metabolism and maintain cell function. Mitochondrial dysfunction is directly …

Disulfides in peptides and proteins are essential for maintaining a properly folded structure.
Their oxidative folding is invariably performed in an aqueous‐buffered solution. However …

Mitochondria are multifunctional subcellular organelles whose operations encompass
energy production, signal transduction, and metabolic regulation. Given their wide range of …

Enhanced targeting approaches will support the treatment of diseases associated with
dysfunctional mitochondria, which play critical roles in energy generation and cell survival …

Chitin-binding hevein-like peptides (CB-HLPs) belong to a family of cysteine-rich peptides
that play important roles in plant stress and defense mechanisms. CB-HLPs are ribosomally …