Neuropathic pain: delving into the oxidative origin and the possible implication of transient receptor potential channels
C Carrasco, M Naziroǧlu, AB Rodríguez… - Frontiers in …, 2018 - frontiersin.org
Currently, neuropathic pain is an underestimated socioeconomic health problem affecting
millions of people worldwide, which incidence may increase in the next years due to …
millions of people worldwide, which incidence may increase in the next years due to …
TRPM2: a candidate therapeutic target for treating neurological diseases
JC Belrose, MF Jackson - Acta Pharmacologica Sinica, 2018 - nature.com
Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca 2+)-permeable non-
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …
The TRPM2 ion channel is required for sensitivity to warmth
CH Tan, PA McNaughton - Nature, 2016 - nature.com
Thermally activated ion channels are known to detect the entire thermal range from extreme
heat (TRPV2), painful heat (TRPV1, TRPM3 and ANO1), non-painful warmth (TRPV3 and …
heat (TRPV2), painful heat (TRPV1, TRPM3 and ANO1), non-painful warmth (TRPV3 and …
TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice
K Haraguchi, A Kawamoto, K Isami… - Journal of …, 2012 - Soc Neuroscience
Accumulating evidence suggests that neuroimmune interactions contribute to pathological
pain. Transient receptor potential melastatin 2 (TRPM2) is a nonselective Ca2+-permeable …
pain. Transient receptor potential melastatin 2 (TRPM2) is a nonselective Ca2+-permeable …
Molecular role of catalase on oxidative stress-induced Ca2+ signaling and TRP cation channel activation in nervous system
M Nazıroğlu - Journal of Receptors and Signal Transduction, 2012 - Taylor & Francis
Background: Catalase catalyzes the reduction of H2O2 to water and it can also remove
organic hydroperoxides. Nervous system in body is especially sensitive to free radical …
organic hydroperoxides. Nervous system in body is especially sensitive to free radical …
Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel
Y Akyuva, M Nazıroğlu - Scientific Reports, 2020 - nature.com
Hypoxia (HYPX) induced-overload Ca2+ entry results in increase of mitochondrial oxidative
stress, inflammation and apoptosis in several neurons. Ca2+ permeable TRPM2 channel …
stress, inflammation and apoptosis in several neurons. Ca2+ permeable TRPM2 channel …
[HTML][HTML] The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin
H Kittaka, M Tominaga - Allergology International, 2017 - Elsevier
Itch is an unpleasant cutaneous sensation that can arise following insect bites, exposure to
plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations …
plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations …
Flufenamic acid as an ion channel modulator
R Guinamard, C Simard, C Del Negro - Pharmacology & therapeutics, 2013 - Elsevier
Flufenamic acid has been known since the 1960s to have anti-inflammatory properties
attributable to the reduction of prostaglandin synthesis. Thirty years later, flufenamic acid …
attributable to the reduction of prostaglandin synthesis. Thirty years later, flufenamic acid …
Store-operated CRAC channel inhibitors: opportunities and challenges
C Tian, L Du, Y Zhou, M Li - Future medicinal chemistry, 2016 - Taylor & Francis
Aberrant Ca2+ release-activated Ca2+ (CRAC) channel activity has been implicated in a
number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular …
number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular …
Pharmacological modulation of TRPM2 channels via PARP pathway leads to neuroprotection in MPTP-induced Parkinson's disease in Sprague dawley rats
Transient receptor potential melastatin-2 (TRPM2) channels are cation channels activated
by oxidative stress and ADP-ribose (ADPR). Role of TRPM2 channels has been postulated …
by oxidative stress and ADP-ribose (ADPR). Role of TRPM2 channels has been postulated …