DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment
Methylation of histone 3 at lysine 79 (H3K79) is one of the principal mechanisms involved in
gene expression. The histone methyltransferase DOT1L, which mono-, di-and trimethylates …
gene expression. The histone methyltransferase DOT1L, which mono-, di-and trimethylates …
CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy
ABSTRACT CARM1 (coactivator associated arginine methyltransferase 1) has recently
emerged as a powerful regulator of skeletal muscle biology. However, the molecular …
emerged as a powerful regulator of skeletal muscle biology. However, the molecular …
Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy
F Roth, J Dhiab, A Boulinguiez, HR Mouigni… - Acta …, 2022 - Springer
Oculopharyngeal muscular dystrophy (OPMD) is a rare muscle disease characterized by an
onset of weakness in the pharyngeal and eyelid muscles. The disease is caused by the …
onset of weakness in the pharyngeal and eyelid muscles. The disease is caused by the …
[HTML][HTML] The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology
Objective Coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes the
methylation of arginine residues on target proteins to regulate critical processes in health …
methylation of arginine residues on target proteins to regulate critical processes in health …
Protein arginine methyltransferase 1 (PRMT1) selective inhibitor, TC-E 5003, has anti-inflammatory properties in TLR4 signaling
Protein arginine methyltransferase 1 (PRMT1) is the most predominant PRMT and is type I,
meaning it generates monomethylarginine and asymmetric dimethylarginine. PRMT1 has …
meaning it generates monomethylarginine and asymmetric dimethylarginine. PRMT1 has …
Arginine methylation of the PGC-1α C-terminus is temperature-dependent
M Mendoza, M Mendoza, T Lubrino, S Briski, I Osuji… - Biochemistry, 2022 - ACS Publications
We set out to determine whether the C-terminus (amino acids 481–798) of peroxisome
proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α, UniProt Q9UBK2), a …
proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α, UniProt Q9UBK2), a …
[HTML][HTML] CARM1 regulates AMPK signaling in skeletal muscle
Coactivator-associated arginine methyltransferase 1 (CARM1) is an emerging mediator of
skeletal muscle plasticity. We employed genetic, physiologic, and pharmacologic …
skeletal muscle plasticity. We employed genetic, physiologic, and pharmacologic …
Arsenic induced epigenetic changes and relevance to treatment of acute promyelocytic leukemia and beyond
Y Maimaitiyiming, QQ Wang, CH Hsu… - Toxicology and Applied …, 2020 - Elsevier
Epigenetic alterations regulate gene expression without changes in the DNA sequence. It is
well-demonstrated that aberrant epigenetic changes contribute to the leukemogenesis of …
well-demonstrated that aberrant epigenetic changes contribute to the leukemogenesis of …
Protein arginine methyltransferase biology in humans during acute and chronic skeletal muscle plasticity
TL VanLieshout, JT Bonafiglia… - Journal of Applied …, 2019 - journals.physiology.org
Protein arginine methyltransferases (PRMTs) are a family of enzymes that catalyze the
methylation of arginine residues on target proteins. While dysregulation of PRMTs has been …
methylation of arginine residues on target proteins. While dysregulation of PRMTs has been …
PRMT1 activates myogenin transcription via MyoD arginine methylation at R121
Q Liu, X Zhang, M Cheng, Y Zhang - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
MyoD is a determining transcription factor involved in myogenic cell differentiation. Post
translational modifications of MyoD, including phosphorylation and acetylation, can regulate …
translational modifications of MyoD, including phosphorylation and acetylation, can regulate …