Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

Abstract Arginase (EC 3.5. 3.1) is the bimanganese enzyme that converts L‐arginine into
ornithine and urea. This enzyme was discovered more than a century ago and early α …

BACKGROUND: Trypanosomatids are early-diverging eukaryotes devoid of the major
disulfide reductases–glutathione reductase and thioredoxin reductase–that control thiol …

Studies of Leishmania donovani have shown that both ornithine decarboxylase and
spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans worldwide. Because a vaccine is not available and the currently small number of …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …

Simple Summary Leishmaniosis is an important zoonotic protozoan disease. Leishmania
infantum is a protozoan species that accounts for the majority of cases in the Mediterranean …

Proliferation of Leishmania (L.) parasites depends on polyamine availability, which can be
generated by the L-arginine catabolism and the enzymatic activity of arginase (ARG) of the …

The plant Cecropia pachystachya Trécul is widely used in Brazilian ethnomedicine to treat
hypertension, asthma, and diabetes. Arginase is an enzyme with levels that are elevated in …

Leishmaniasis is a complex of neglected tropical diseases caused by various species of
leishmanial parasites that primarily affect the world's poorest people. A limited number of …