Tacrine derivatives and Alzheimer's disease
V Tumiatti, A Minarini, ML Bolognesi… - Current medicinal …, 2010 - ingentaconnect.com
To date, the pharmacotherapy of Alzheimer's disease (AD) has relied on
acetylcholinesterase (AChE) inhibitors (AChEIs) and, more recently, an N-methyl-D …
acetylcholinesterase (AChE) inhibitors (AChEIs) and, more recently, an N-methyl-D …
New Perspectives on Chinese Herbal Medicine (Zhong‐Yao) Research and Development
SY Pan, SB Chen, HG Dong, ZL Yu… - Evidence‐Based …, 2011 - Wiley Online Library
Synthetic chemical drugs, while being efficacious in the clinical management of many
diseases, are often associated with undesirable side effects in patients. It is now clear that …
diseases, are often associated with undesirable side effects in patients. It is now clear that …
Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors
H Liu, X Liu, H Fan, J Tang, X Gao, WK Liu - Bioorganic & medicinal …, 2014 - Elsevier
A novel series of chalcone derivatives (4a–8d) were designed, synthesized, and evaluated
for the inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase …
for the inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase …
Non-neuronal role of acetylcholinesterase in bone development and degeneration
Acetylcholinesterase (AChE), an enzyme catalyzing the degradation of acetylcholine, plays
an important suppressive role in the cholinergic regulation by terminating the action of …
an important suppressive role in the cholinergic regulation by terminating the action of …
Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases …
Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, are
devastating diseases in the elderly world, which are closely associated with progressive …
devastating diseases in the elderly world, which are closely associated with progressive …
Novel anti-Alzheimer's dimer bis (7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets
W Li, M Mak, H Jiang, Q Wang, Y Pang, K Chen… - …, 2009 - Springer
Alzheimer's disease (AD) is a progressive and degenerative brain disorder that has
emerged as one of the major public health problems in adults. Unfortunately, its molecular …
emerged as one of the major public health problems in adults. Unfortunately, its molecular …
Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B
A novel series of flavokawain B derivatives, chalcone Mannich bases (4–10) were designed,
synthesized, characterized, and evaluated for the inhibition activity against …
synthesized, characterized, and evaluated for the inhibition activity against …
Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives
A series of hybrids containing tacrine linked to carbohydrate-based moieties, such as d-
xylose, d-ribose, and d-galactose derivatives, were synthesized by the nucleophilic …
xylose, d-ribose, and d-galactose derivatives, were synthesized by the nucleophilic …
Structure–activity relationship investigation of benzamide and picolinamide derivatives containing dimethylamine side chain as acetylcholinesterase inhibitors
X Gao, L Liu, H Liu, J Tang, L Kang, H Wu… - Journal of enzyme …, 2018 - Taylor & Francis
A series of benzamide and picolinamide derivatives containing dimethylamine side chain
(4a–4c and 7a–7i) were synthesised and evaluated for acetylcholinesterase (AChE) and …
(4a–4c and 7a–7i) were synthesised and evaluated for acetylcholinesterase (AChE) and …
Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side …
X Gao, C Zhou, H Liu, L Liu, J Tang… - Journal of enzyme …, 2017 - Taylor & Francis
A new series of tertiary amine derivatives of chlorochalcone (4a∼ 4l) were designed,
synthesized and evaluated for the effect on acetylcholinesterase (AChE) and …
synthesized and evaluated for the effect on acetylcholinesterase (AChE) and …