Making sense of the ageing methylome

K Seale, S Horvath, A Teschendorff, N Eynon… - Nature Reviews …, 2022 - nature.com
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

[HTML][HTML] Epidrugs in the clinical management of atherosclerosis: Mechanisms, challenges and promises

S Panduga, S Vasishta, R Subramani, S Vincent… - European Journal of …, 2024 - Elsevier
Atherosclerosis is a complex and multigenic pathology associated with significant epigenetic
reprogramming. Traditional factors (age, sex, obesity, hyperglycaemia, dyslipidaemia …

[HTML][HTML] Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer

L Wang, M Li, H Yang, F Dai, N Xie, L Li, M Zhu… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Background: Breast cancer (BC) is a heterogeneous tumor with a variety of etiology and
clinical features. Antibody-dependent cell phagocytosis (ADCP) is the last step of immune …

LncRNA Pvt1 aggravates cardiomyocyte apoptosis via the microRNA-216/Ccnd3 axis

Y Hu, M Luo, Y Xue, D Lv, L Huang, X Li, J Shen - Heliyon, 2024 - cell.com
Objective Our study aims to evaluate the role of long non-coding RNA variant translocation
gene Pvt1 in cardiomyocyte apoptosis, as well as the potential targets and mechanisms …

From 'omics to multi-omics technologies: the discovery of novel causal mediators

P Mohammadi-Shemirani, T Sood, G Paré - Current atherosclerosis …, 2023 - Springer
Abstract Purpose of Review 'Omics studies provide a comprehensive characterisation of a
biological entity, such as the genome, epigenome, transcriptome, proteome, metabolome, or …

Integrated Analysis of Gene Expression and Methylation Data to Identify Potential Biomarkers Related to Atherosclerosis Onset

X Li, X Dong, W Lu, K Yang, X Li - Oxidative Medicine and …, 2022 - Wiley Online Library
Atherosclerosis is a kind of chronic inflammatory cardiovascular disease. Epigenetic
regulation plays a crucial role in atherosclerosis. Our study was aimed at finding potential …

[HTML][HTML] LncRNA-TCONS_00034812 is upregulated in atherosclerosis and upregulates miR-21 through methylation in vascular smooth muscle cells

D Lin, X Zhang, C Zhang, Q Jin… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background LncRNA-TCONS_00034812 is a critical player in the proliferation of aortic
smooth muscle cells. It is known that artery injury plays an important role in atherosclerosis …

Novel biomarkers identified by weighted gene co-expression network analysis for atherosclerosis

J Ni, K Huang, J Xu, Q Lu, C Chen - Herz, 2024 - Springer
Background This study aimed to screen out the potential diagnostic biomarkers for
atherosclerosis (AS). Methods We downloaded the gene expression profiles GSE66360 …

Quantifying the ageing methylome: a multi-tissue map in humans

K Seale - 2023 - vuir.vu.edu.au
The epigenome is a dynamic system of chemical modifications that operate to control
chromatin structure and regulate gene activity without altering the underlying DNA …

Identification of subtype recognition and prognosis model characterized by Antibody-dependent cell phagocytosis related genes in breast cancer

L Wang, M Li, H Yang, F Dai, N Xie, L Li, M Zhu, R Ding - 2023 - researchsquare.com
Background Breast cancer (BC) is a heterogeneous tumor with a variety of etiology and
clinical features. Antibody-dependent cell phagocytosis (ADCP) is the last step of immune …