The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

We identified individuals with variations in ACTL6B, a component of the chromatin
remodeling machinery including the BAF complex. Ten individuals harbored bi-allelic …

The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …

Transcription factors regulate multiple processes during brain development and in the adult
brain, from brain patterning to differentiation and maturation of highly specialized neurons as …

The ability to convert human somatic cells efficiently to neurons facilitates the utility of patient-
derived neurons for studying neurological disorders. As such, ectopic expression of …

The eukaryotic genetic material is packaged in the form of chromatin by wrapping DNA
around nucleosomes. Cells maintain chromatin in a dynamic state by utilising various ATP …

Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadly as
either synaptic or developmental. But what if this is a false distinction? A recent spate of …

Highlights•New evidence shows that chromatin regulation is highly dynamic during memory
formation.•Chromatin is modified by incorporating functionally distinct histone variants to …

Abstract Mammalian SWI/SNF/BAF chromatin remodeling complexes influence cell lineage
determination. While the contribution of these complexes to neural progenitor cell (NPC) …